The research team led by Dr. Brenda Gallie from the Princess Margaret Cancer Center at the University Health Network (UHN), based in Toronto, found that this aggressive retinoblastoma is caused by the presence of a single cancer gene or oncogenes in infants, even these cancer cells can attack since the baby is still in the baby. the mother’s womb. Worse, this type of eye cancer is vulnerable to attack and is found in children from families who have no history of eye cancer. Dr. Brenda Gallie stated, Retinoblastoma which is found usually begins with damage to both copies of the tumor suppressor gene, RB1. And also in many cases found, retinoblastoma with this type tends to be hereditary and can attack one or even both eyes of the child, including the same risks that will be experienced by his siblings, explained the doctor.
But in contrast to this new eye cancer, after they removed a large tumor in an infant patient who was so young, from there they found that there were oncogens that could cause the emergence of this new type of retinoblastoma. But oddly the eyes of a baby or other child who comes from the same family member are not at risk of developing the same retinoblastoma, he added. Moreover, the tumors caused by this oncogene will also be larger in size than the tumors in children with ‘inherited’ retinoblastoma at the same age. As reported by Dr. zeenews Gallie explains, “Initial diagonysis can be done by ascertaining whether the pupils in their child’s eyes are white or otherwise black, he explained.”
However, even though until now, although the number of unilateral retinoblastoma tumors that occur is only two percent, it is predicted that about 1 in 5 babies who have been diagnosed with eye cancer when they are under six months are actually retinoblastoma that infects these babies, the cause is many triggered by oncogens. But fortunately all babies affected by this new type of eye tumor can be cured by going through surgery. Dr. Gilie and previous researchers assumed that the retinoblastoma tumor must have occurred because it was triggered by the loss of the retinoblastoma gene. However, this study reveals a new fact that a new type of retinoblastoma whose retinoblastoma gene is normal but is caused by extra copies originating from a cancer gene that is so strong that it can cause the growth of cancer cells so fast before the baby is born. “Learning from previous eye cancer cases, the average patient is diagnosed when he was only four months, he concluded.” This official study has been published in the research journal ‘Lancet Oncology’.